ABSTRACT
Tramadol is a weak mu (µ) opioid receptor agonist that acts by inhibiting serotonin and norepinephrine uptake. Tramadol undergoes extensive hepatic metabolism by a number of pathways, including CYP2D6 and CYP3A4, and by conjugation with subsequent renal excretion. The maximum recommended dose is 400 mg/day. One of the most important adverse effects of tramadol is a seizure, which usually occurs at high doses and is often generalized tonic–clonic type and self-limiting. Here, we present a case of a patient with inflammatory low backache who developed seizures while on low-dose oral tramadol. After 1 h of taking the first tablet of tramadol, he developed morbilliform rashes all over the body. One day later, he developed generalized tonic–clonic seizures followed by a loss of consciousness for 5 min. The patient was admitted to the hospital and managed conservatively with injection lorazepam and tramadol was stopped. In general, if applied in overdose, tramadol can only incite seizures in patients already suffering from some sort of disorder related to seizures or if it is administered along with antidepressants, alcohol, etc. But here, only with the use of 37.5 mg oral application, the incidence of seizure happened.
ABSTRACT
Anemia is a major public health problem in India affecting over half of population in almost all age groups. It has devastating effect on human health and affects the socio-economic development. Government has devised several programs like National Nutritional Anemia Control Program (NNACP), Weekly Iron and Folic Acid Supplementation (WIFS), National Iron Plus Initiative (NIPI) etc to combat anemia. The facts remain that in spite of all the programs, no marked improvement has been noticed in the magnitude of anemia. A holistic approach is required with special emphasis on community awareness about consequences of anaemia and benefits of Iron Folic Acid (IFA) supplementation, uninterrupted supply availability of Iron folic Acid tablets and syrups, hard to reach areas and monitoring and review system to find out adequacy in terms of participation and frequency of meetings and problem-solving in NIPI